Programme

Monday, November 28, 2016

Time Event  
09:30 - 09:45 Coffee & Croissant  
09:45 - 10:00 Welcome, introduction to workshop - by Huib Mansvelder, Idan Segev and Alain Destexhe  
10:00 - 10:45 Engineering the human cortical column: what is holding us back? - Christiaan de Kock (Vrije Universiteit Amsterdam)  
10:45 - 11:30 Unique Membrane and Enhanced Computations in Human Neocortical Neurons - Guy Eyal (The Hebrew University of Jerusalem)  
11:30 - 11:45 Coffee break  
11:45 - 12:30 Functional studies on human ex vivo brain slices at the Allen Institute - Jonathan Ting (Allen Institute)  
12:30 - 13:00 Moderated discussion 1 - Topics: - Can we use a general coordinate system (in MRI space?), as the Allen Inst system for the mouse? - What tools will allow us to reveal anatomical landmarks in human (temporal) cortex? - do we have tools to reveal cortical column borders in human (temporal) cortex and if not, which markers should we test to find possible column borders? - do we think about columns in temporal cortex?  
13:00 - 14:00 Lunch  
14:00 - 14:45 A quantitative Morphological and Biophysical Analysis of L2/3 Pyramidal Neurons from Human Temporal Cortex - Yair Detcher (The Hebrew University of Jerusalem)  
14:45 - 15:30 Human neuronal network properties - Taufik Valiante (Krembil Research Institute, University of Toronto)  
15:30 - 16:00 Moderated discussion 2 - Topics: - are we limited to temporal cortex - How do we get dendritic physiology in human cell? (including synaptic inputs properties and dendritic nonlinearities)  
16:00 - 16:15 Coffee break  
16:15 - 17:00 Dynamics of excitatory and inhibitory neurons identified from the human temporal lobe with multi-electrode arrays - Alain Destexhe (UNIC EITN, CNRS)  
17:00 - 17:45 Moderated discussion 3 - Topics: - How do we align and combine efforts by different research groups? - Can we link cell types identified in vitro, to units recorded in vivo?  

Tuesday, November 29, 2016

Time Event  
08:30 - 08:45 Coffee & Croissant  
08:45 - 09:30 Reverse engineering the human cortical microcircuit by the Allen Institute - Ed Lein (Allen Institute)  
09:30 - 10:15 Microanatomy of pyramidal neurons" OR "The Pyramidal neuron in cognition - Javier DeFelipe (Instituto Cajal, CSIC)  
10:15 - 10:45 Moderated discussion 4 - Topics: - Can every neocortical cell be assigned to a unique type defined by transcriptional, morphological, physiological and connectivity properties? - How can these types be arranged in a taxonomy? - How do cell types differ between mice and humans?  
10:45 - 11:00 Coffee break  
11:00 - 11:45 What can we expect if we reconstruct and simulate the human neocortical microcircuitry? - Henry Markram (EPFL)  
11:45 - 12:15 First steps in characterization of inhibitory inputs to human cortical pyramidal neurons - Natalia Goriounova (Vrije Universiteit Amsterdam)  
12:15 - 13:00 Moderated discussion 5 - Topics: - How do we collectively enhance the reconstruction and simulation of large scale cortical microcircuits in human? - e-codes, which profiles? To feed the models - standardization of protocols - what file formats? Common file formats?  
13:00 - 14:00 Lunch  
14:00 - 14:45 Firing frequency maxima of fast-spiking neurons in human, monkey and mouse neocortex - Yousheng Shu (Beijing Normal University)  
14:45 - 15:30 Pyramidal neuron to interneuron synapses - Gábor Tamás (University of Szeged)  
15:30 - 15:45 Coffee break  
15:45 - 16:30 Plasticity of human excitatory synapses - Huib Mansvelder (Vrije Universiteit Amsterdam)  
16:30 - 17:15 Moderated discussion 6 - Topics: - Where do we go from here? - how do we deal with variability (outbred human population)? - can we use postmortem brain? How do you get morphology, physiology and molecular profile from the same cells?  
17:15 - 17:45 Conclusion  
  
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