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Monday, November 28, 2016
Time | Event | |
09:30 - 09:45 | Coffee & Croissant | |
09:45 - 10:00 | Welcome, introduction to workshop - by Huib Mansvelder, Idan Segev and Alain Destexhe | |
10:00 - 10:45 | Engineering the human cortical column: what is holding us back? - Christiaan de Kock (Vrije Universiteit Amsterdam) | |
10:45 - 11:30 | Unique Membrane and Enhanced Computations in Human Neocortical Neurons - Guy Eyal (The Hebrew University of Jerusalem) | |
11:30 - 11:45 | Coffee break | |
11:45 - 12:30 | Functional studies on human ex vivo brain slices at the Allen Institute - Jonathan Ting (Allen Institute) | |
12:30 - 13:00 | Moderated discussion 1 - Topics: - Can we use a general coordinate system (in MRI space?), as the Allen Inst system for the mouse? - What tools will allow us to reveal anatomical landmarks in human (temporal) cortex? - do we have tools to reveal cortical column borders in human (temporal) cortex and if not, which markers should we test to find possible column borders? - do we think about columns in temporal cortex? | |
13:00 - 14:00 | Lunch | |
14:00 - 14:45 | A quantitative Morphological and Biophysical Analysis of L2/3 Pyramidal Neurons from Human Temporal Cortex - Yair Detcher (The Hebrew University of Jerusalem) | |
14:45 - 15:30 | Human neuronal network properties - Taufik Valiante (Krembil Research Institute, University of Toronto) | |
15:30 - 16:00 | Moderated discussion 2 - Topics: - are we limited to temporal cortex - How do we get dendritic physiology in human cell? (including synaptic inputs properties and dendritic nonlinearities) | |
16:00 - 16:15 | Coffee break | |
16:15 - 17:00 | Dynamics of excitatory and inhibitory neurons identified from the human temporal lobe with multi-electrode arrays - Alain Destexhe (UNIC EITN, CNRS) | |
17:00 - 17:45 | Moderated discussion 3 - Topics: - How do we align and combine efforts by different research groups? - Can we link cell types identified in vitro, to units recorded in vivo? |
Tuesday, November 29, 2016
Time | Event | |
08:30 - 08:45 | Coffee & Croissant | |
08:45 - 09:30 | Reverse engineering the human cortical microcircuit by the Allen Institute - Ed Lein (Allen Institute) | |
09:30 - 10:15 | Microanatomy of pyramidal neurons" OR "The Pyramidal neuron in cognition - Javier DeFelipe (Instituto Cajal, CSIC) | |
10:15 - 10:45 | Moderated discussion 4 - Topics: - Can every neocortical cell be assigned to a unique type defined by transcriptional, morphological, physiological and connectivity properties? - How can these types be arranged in a taxonomy? - How do cell types differ between mice and humans? | |
10:45 - 11:00 | Coffee break | |
11:00 - 11:45 | What can we expect if we reconstruct and simulate the human neocortical microcircuitry? - Henry Markram (EPFL) | |
11:45 - 12:15 | First steps in characterization of inhibitory inputs to human cortical pyramidal neurons - Natalia Goriounova (Vrije Universiteit Amsterdam) | |
12:15 - 13:00 | Moderated discussion 5 - Topics: - How do we collectively enhance the reconstruction and simulation of large scale cortical microcircuits in human? - e-codes, which profiles? To feed the models - standardization of protocols - what file formats? Common file formats? | |
13:00 - 14:00 | Lunch | |
14:00 - 14:45 | Firing frequency maxima of fast-spiking neurons in human, monkey and mouse neocortex - Yousheng Shu (Beijing Normal University) | |
14:45 - 15:30 | Pyramidal neuron to interneuron synapses - Gábor Tamás (University of Szeged) | |
15:30 - 15:45 | Coffee break | |
15:45 - 16:30 | Plasticity of human excitatory synapses - Huib Mansvelder (Vrije Universiteit Amsterdam) | |
16:30 - 17:15 | Moderated discussion 6 - Topics: - Where do we go from here? - how do we deal with variability (outbred human population)? - can we use postmortem brain? How do you get morphology, physiology and molecular profile from the same cells? | |
17:15 - 17:45 | Conclusion |